Welcome to the Lord Research Group
University of East Anglia (UEA)
We are based in the School of Chemistry at the University of East Anglia, Norfolk, where we have access to state-of-the-art laboratories for synthetic chemistry, analytical chemistry and chemical biology.
Our research focuses on the design and synthesis of transition metal compounds and assessing their potential as anti-cancer drugs. All of our complexes are characterised by NMR spectroscopy, mass spectrometry, elemental analysis, UV-vis spectroscopy and both powder and single X-ray crystallography.
Our main focus is to use the oxidation states and ligand environments of these metal complexes, in order to tune their uptake, distribution and targeting with cancerous cells. We use a range chemical biology techniques, whole-cell ICP-MS, whole-cell EPR and 3D cell culture models, to provide an understand of the metal content within “tumour-like” environments. Working alongside computational experts to help model these biological systems and assess the intracellular interactions with our compounds.