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Welcome to the Lord Research Group

University of East Anglia (UEA)

University of East Anglia campus

We are based in the School of Chemistry at the University of East Anglia, Norfolk, where we have access to state-of-the-art laboratories for synthetic chemistry, analytical chemistry and chemical biology.

Our research focuses on the design and synthesis of transition metal compounds and assessing their potential as anti-cancer drugs. All of our complexes are characterisation by NMR spectroscopy, mass spectrometry, elemental analysis, UV-vis spectroscopy and both powder and single X-ray crystallography.

Single crystals of an organic ligand and the analogues iridium complex

Our main focus is to use the oxidation states and ligand environments of these metal complexes, in order to tune their uptake, distribution and targeting with cancerous cells. We use a range chemical biology techniques, whole-cell ICP-MS, whole-cell EPR and 3D cell culture models, to provide an understand of the metal content within “tumour-like” environments. We work alongside computational experts to help model these biological systems and assess the intracellular interactions with our compounds.

If you would like any more information, please either visit Rianne’s staff page, follow us on Twitter or contact her via r.lord@uea.ac.uk